Journal
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
Volume 81, Issue -, Pages 168-172Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmbbm.2018.01.033
Keywords
PMMA; Sterilization; Personalized medical device; PSI; Pre-treatment
Funding
- Dutch Technology Foundation STW part of the Netherlands Organisation for Scientific Research (NWO) [14326]
- Ministry of Economic Affairs
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Background: Nowadays, personalized medical devices are frequently used for patients. Due to the manufacturing procedure sterilization is required. How different sterilization methods affect the mechanical behavior of these devices is largely unknown. Materials and methods: Three poly(methyl methacrylate) (PMMA) based materials (Vertex Self-Curing, Palacos R + G, and NextDent C&B MFH) were sterilized with different sterilization methods: ethylene oxide, hydrogen peroxide gas plasma, autoclavation, and gamma-irradiation. Mechanical properties were determined by testing the flexural strength, flexural modulus, fracture toughness, and impact strength. Results: The flexural strength of all materials was significantly higher after gamma-irradiation compared to the control and other sterilization methods, as tested in a wet environment. NextDent C&B MFH showed the highest flexural and impact strength, Palacos R + G showed the highest maximum stress intensity factor and total fracture work. Conclusion: Autoclave sterilization is not suitable for the sterilization of PMMA-based materials. Ethylene oxide, hydrogen peroxide gas plasma, and gamma-irradiation appear to be suitable techniques to sterilize PMMA-based personalized medical devices.
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