Modified octyl-2-cyanoacrylate tissue adhesive for the closure of long surgical incisions

Long surgical incisions required application of more flexible cyanoacrylate adhesive to relieve skin tension. A new formulation of octyl-2-cyanoacrylate (OCA) was modified by 0%, 3%, 6% and 9% (w/v) polytrimethylene carbonate (PTMC). The OCA/PTMC adhesives showed higher viscosity and bond strength than OCA monomer. The OCA/6% PTMC adhesive plus subcutaneous suture was used as group A (Treatment group), and the OCA/6% PTMC tissue adhesive alone was used as group B (Control group). 30 days later, there was no apparent scar formation in group A. A linear scar formation still could be seen in group B. The results supported the use of OCA/6% PTMC adhesive alone or adhesive plus subcutaneous suture in long surgical incisions, and the latter maintained better scar formation.