Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 38, Issue -, Pages E189-E197Publisher
WILEY
DOI: 10.1002/hed.23969
Keywords
oral squamous cell carcinoma (OSCC); microRNA; recurrence; prognosis; signature
Categories
Funding
- AIRC [AIRC 14455, AIRC 10728]
- Epigen [13/05/R/42]
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Background. Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide with a high rate of recurrence. MicroRNAs (miRNAs) are gene regulators playing an important role in oral carcinogenesis. The purpose of this study was for us to identify and functionally characterize miRNAs that predict recurrence in OSCC. Methods. We collected 92 OSCC with their normal tissue counterparts and we performed miRNAs expression profiling on 74 OSCC and 38 normal tissues. The association between the expression of miRNAs and clinical outcome was evaluated in the follow-up of 69 patients. Results. Four of the miRNAs deregulated between OSCC and normal tissues are prognostic for recurrence either when considered individually or as a group. Depletion of the expression of prognostic miRNAs inhibit the proliferation of OSCC cells Conclusion. MiRNAs are differentially expressed in OSCC versus normal samples. The expression of 4 prognostic miRNA signatures is able to predict recurrence risk independently from other clinical factors in OSCC. (C) 2015 Wiley Periodicals, Inc.
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