Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 38, Issue -, Pages E884-E889Publisher
WILEY
DOI: 10.1002/hed.24120
Keywords
squamous cell carcinoma; metastasis; skin cancer; head and neck; sentinel node biopsy
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Background. Nodal metastasis from cutaneous squamous cell carcinoma (SCC) is poorly predicted clinically and is associated with a high mortality rate. Methods. From 2010 to 2013, patients with high-risk cutaneous SCC were assessed with sentinel node biopsy (SNB) either at the time of primary cutaneous tumor resection or at secondary wide local excision. Results. Of 57 patients, 8 (14%) had nodal metastasis. Significant predictors of metastasis are the number of high-risk factors (p=.008), perineural invasion (PNI; p=.05), and lymphovascular invasion (LVI; p=.05). During a mean of 19.4 months, 9 patients developed recurrence and 6 died of cutaneous SCC, indicating that over 1300 patients would be required for a randomized controlled trial with 80% power to detect a significant difference in disease-free survival. Conclusion. Lymph node metastasis occurs in 14% of patients with high-risk cutaneous SCC. Larger studies will be required to identify which high-risk factors should be considered as an indication for surgical assessment of the nodal basin. (c) 2015 Wiley Periodicals, Inc.
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