Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 38, Issue 4, Pages 542-549Publisher
WILEY-BLACKWELL
DOI: 10.1002/hed.23929
Keywords
head and neck squamous cell carcinoma; 4-1BB; immunotherapy; small-animal positron emission tomography (PET)-CT; longitudinal positron emission tomography (PET)-MRI
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Funding
- Deutsche Forschungsgemeinschaft
- Interdisciplinary Center for Clinical Research (IZKF core unit PIX), University of Munster, Germany
- Bartling stiftung
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Background. Recent technical progress makes sophisticated noninvasive imaging methods available for murine models. For the first time, in this study, we applied fluorodeoxyglucose (FDG)-positron emission tomography (PET)-CT and FDG-PET-MRI to a murine orthotopic model of head and neck cancer immunotherapy. Methods. Tumor growth of floor of the mouth tumors was evaluated by multimodal small-animal imaging using FDG-PET-CT and FDG-PET-MRI. The immunotherapeutic effects of anti-CD137 antibody therapy were examined on body weight, tumor growth, and tumor-infiltrating immune cells in longitudinal imaging studies and immunohistochemical analyses. Results. Imaging revealed aggressive, fast-growing tumors without evidence of local or distant metastases. CD137 immunotherapy decreased tumor take and growth and stabilized body weight over time. A clear case of tumor regression was demonstrated by longitudinal PET-CT. Conclusion. The murine model mimics the characteristics of head and neck cancer in humans and offers excellent opportunities to investigate immunomodulatory anticancer drugs. The CD137 antibody showed antitumor effects in some therapy-responsive mice. (C) 2015 Wiley Periodicals, Inc.
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