Journal
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
Volume 65, Issue 9, Pages 1136-1146Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jccs.201800157
Keywords
biohybrid; cathodoluminescence; correlative light-electron microscopy; imaging; nanodiamond
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Funding
- Ministry of Science and Technology, Taiwan [106-2628-M-001-004]
- Academia Sinica
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Cathodoluminescence (CL) and correlative light-electron microscopy (CLEM) are two useful analytical tools in diverse research areas. Recently, fluorescent nanodiamonds (FNDs) have emerged as promising imaging agents for both CL and CLEM owing to their exceptional photophysical and chemical properties. However, to realize their practical applications in the life sciences, surface modification and functionalization of the nanomaterials with bioactive molecules are critical and essential. Here we provide a comprehensive review on the methods of synthesizing biohybrid FNDs as well as recent advances of CL and CLEM imaging of cells with these carbon nanoparticles as dual-contrast markers.
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