Journal
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Volume 29, Issue 6, Pages 1596-1600Publisher
AMER SOC NEPHROLOGY
DOI: 10.1681/ASN.2017070800
Keywords
transplantation; rejection; lymphocytes; intravital multiphoton microscopy; effector CD8 T cells; dendritic cells
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Funding
- National Institutes of Health [5R01 AI49466, 4P30 DK079307]
- John Merrill Grant in Transplantation (American Society of Nephrology)
- American Society of Transplantation
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Kidney transplantation is the treatment of choice for ESRD but is complicated by the response of the recipient's immune system to nonself histocompatibility antigens on the graft, resulting in rejection. Multiphoton intravital microscopy, referred to as four-dimensional imaging because it records dynamic events in three-dimensional tissue volumes, has emerged as a powerful tool to study immunologic processes in living animals. Here, we will review advances in understanding the complex mechanisms of T cell-mediated rejection made possible by four-dimensional imaging of mouse renal allografts. We will summarize recent data showing that activated (effector) T cell migration to the graft is driven by cognate antigen presented by dendritic cells that surround and penetrate peritubular capillaries, and that T cell-dendritic cell interactions persist in the graft over time, maintaining the immune response in the tissue.
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