Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 140, Issue 8, Pages 2801-2804Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b00515
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Funding
- National Natural Science Foundation of China [21775018, 21675022, 21627806]
- Natural Science Foundation of Jiangsu Province [BK20160028, BK20170084]
- Open Funds of the State Key Laboratory of Electroanalytical Chemistry [SKLEAC201703]
- Fundamental Research Funds for the Central Universities
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Natural selection over billions of years has developed highly effective in vivo signal transduction that is often governed by a series of competitive multiple mechanisms. Several artificial signal transduction pathways have inspired numerous biosensing systems, but most of these are driven by a single mechanism. Herein we describe a multiple-mechanism-driven electrochemiluminescent (ECL) biosensor that utilizes competitive catalytic and steric hindrance effects by assembling hemin/G-quadruplex on carbon nitride nanosheets. Taking the detection of 8-hydroxy-2'-deoxyguanosine (8-OHdG) as example, the dynamic ranges of the detectable concentrations from the different mechanisms were integrated into a single sensor interface. Moreover, the detection sensitivity was more precisely controlled by the competition between the two mechanisms and inherently boosted compared with that of single-mechanism-driven detection. Going beyond the conventional single-mechanism-driven biosensing, the elaborate biomimetic coupling of multiple mechanisms in a single interface may open a new approach for future multiplexed biosensing.
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