Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 140, Issue 7, Pages 2460-2464Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b00391
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Funding
- MOST [2016YFA0204100]
- NSFC [21672178, 21603227]
- Thousand Youth Talents Plan
- Fundamental Research Funds
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An unprecedented radical difluoromethylarylation reaction of alkynes has been developed by discovering a new difluoromethylation reagent, CF(2)HSO(2)NTHNHBoc. This air-stable and solid reagent can be prepared in one step from commercially available reagents CF2FISO2Cl and NH(2)NHBoc. The CF2H radical, generated through ferrocene-mediated electrochemical oxidation, participates in an unexplored alkyne addition reaction followed by a challenging 7-membered ring-forming homolytic aromatic substitution step to afford fluorinated dibenzazepines.
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