Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 140, Issue 29, Pages 9061-9065Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b04902
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Funding
- 1000-Youth Talents Plan
- National Natural Science Foundation of China [2167020084]
- National Natural Science Foundation of Jiangsu Province [BK20170632]
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A copper-catalyzed system has been introduced for the enantioselective defluoroalkylation of linear 1-(trifluoromethyl)alkenes through C-F activation to synthesize various gem-difluoroalkenes as carbonyl mimics. For the first time, arylboronate-activated alkyl Grignard reagents were uncovered in this cross-coupling reaction. Mechanistic studies confirmed that the tetraor-ganoborate complexes generated in situ were the key reactive species for this transformation.
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