Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 140, Issue 15, Pages 4977-4981Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.8b00275
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Funding
- National Natural Science Foundation of China [21402145, 21432007, 21372179]
- Youth Chen-Guang Science and Technology Project of Wuhan City [2015071704011640]
- Fundamental Research Funds for Central Universities [2042017kf0177]
- Important Sci-Tech Innovative Project of Hubei Province [2015ACA058]
- 111 Project of the Ministry of Education of China
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A series of novel hybrid phosphorus ligands were designed and applied to the Rh-catalyzed enantioselective anti-Markovnikov hydroformylation of unfunctionalized 1,1-disubstituted alkenes. By employing the new catalyst, linear aldehydes with beta-chirality can be prepared with high yields and enantioselectivities under mild conditions. Furthermore, catalyst loading as low as 0.05 mol % furnished the desired product in good yield and undiminished selectivity, demonstrating the efficiency of this transformation in large-scale synthesis.
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