Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 140, Issue 5, Pages 1617-1621Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b13361
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Funding
- ETH Zurich
- Swiss National Science Foundation [310030B_163479/1, SINERGIA CRSII2_160699/1]
- ERC Advanced Grant Zauberkugel [670603]
- Kommission fur Technologie und Innovation [17072.1]
- Novartis Foundation for medical-biological Research
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We present the first direct comparative evaluation of an antibody drug conjugate and of a small molecule drug conjugate for cancer therapy, using chemically defined products which bind with high-affinity to carbonic anhydrase IX, a marker of tumor hypoxia and of renal cell carcinoma.
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