Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 140, Issue 13, Pages 4469-4472Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b12505
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Funding
- MINECO [MAT2017-86659-R, SAF2016-76689-R, FJCI-2015-25080, IJCI-2014-19326]
- Xunta de Galicia [2015CP082, ED431C 2017/19, ED431G/09]
- European Regional Development Fund
- European Research Council [340055]
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We describe an approach to regulate the cellular uptake of small gold nanoparticles using supra molecular chemistry. The strategy relies on the functionalization of AuNPs with negatively charged pyranines, which largely hamper their penetration in cells. Cellular uptake can be activated in situ through the addition of cationic covalent cages that specifically recognize the fluorescent pyranine dyes and counterbalance the negative charges. The high selectivity and reversibility of the host guest recognition activates cellular uptake, even in protein rich biological media, as well as its regulation by rational addition of either cage or pyranine.
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