Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 78, Issue 1, Pages 29-+Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaad.2017.09.012
Keywords
aging; facial skin appearance; gene expression; genetics; intrinsic aging; photoaging; photoprotection; pigmentation; transcriptomics
Categories
Funding
- Procter Gamble
Ask authors/readers for more resources
Background: Intrinsic and extrinsic factors, including ultraviolet irradiation, lead to visible signs of skin aging. Objective: We evaluated molecular changes occurring in photoexposed and photoprotected skin of white women 20 to 74 years of age, some of whom appeared substantially younger than their chronologic age. Methods: Histologic and transcriptomics profiling were conducted on skin biopsy samples of photoexposed (face and dorsal forearm) or photoprotected (buttocks) body sites from 158 women. 23andMe genotyping determined genetic ancestry. Results: Gene expression and ontologic analysis revealed progressive changes from the 20s to the 70s in pathways related to oxidative stress, energy metabolism, senescence, and epidermal barrier; these changes were accelerated in the 60s and 70s. The gene expression patterns from the subset of women who were younger-appearing were similar to those in women who were actually younger. Limitations: Broader application of these findings (eg, across races and Fitzpatrick skin types) will require further studies. Conclusions: This study demonstrates a wide range of molecular processes in skin affected by aging, providing relevant targets for improving the condition of aging skin at different life stages and defining a molecular pattern of epidermal gene expression in women who appear younger than their chronologic age.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available