Journal
ORTHOPEDIC REVIEWS
Volume 6, Issue 4, Pages 168-174Publisher
PAGEPRESS PUBL
DOI: 10.4081/or.2014.5575
Keywords
fracture; large animal; sheep; fracture healing; non-osteotomy fracture model
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [SFB 599, TP D10]
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Large animal fracture models are important in the field of orthopedic trauma research. New implants are tested in animals before being implanted into humans. Large animals like sheep or swine often are more properly to simulate conditions in humans, e.g. biomechanical demands, compared to rodents. Cited articles mainly analyze shock or fracture healing. Both osteotomy and non-osteotomy fracture models have been used in the past. However, comparative studies are rare and clear recommendation when to use which model are missing. This review will summarize large animal fracture models putting special emphasis on non-osteotomy fracture models.
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