Journal
JOURNAL OF SUPERCRITICAL FLUIDS
Volume 132, Issue -, Pages 105-125Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.supflu.2017.03.005
Keywords
Precipitation; Adsorption; Amorphization; Supercritical carbon dioxide; Drug delivery systems
Categories
Funding
- DFG [SM 82/8-1, SM 82/8-2, SM 82/8-3, 1570]
- DAAD
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In this review, available experimental data on the drug confinement in porous matrices via adsorptive precipitation from supercritical fluid solutions with a special emphasis on the drug amorphization is provided. Practical aspects and opportunities for the process optimization are discussed in view of thermodynamic considerations. An attempt is made to elaborate a simplified model that takes into account drug drug and drug matrix interactions with the aim of rationalizing the experimental outcomes with respect to the physical state of the confined drug. Potential points of growth and some bottlenecks of the adsorptive precipitation from supercritical solutions are outlined. (C) 2017 Elsevier B.V. All rights reserved.
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