Journal
GENOME BIOLOGY
Volume 15, Issue 10, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s13059-014-0488-x
Keywords
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Funding
- European Research Council [DENOVO 281964]
- Dutch national program COMMIT
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Mobile elements are major drivers in changing genomic architecture and can cause disease. The detection of mobile elements is hindered due to the low mappability of their highly repetitive sequences. We have developed an algorithm, called Mobster, to detect non-reference mobile element insertions in next generation sequencing data from both whole genome and whole exome studies. Mobster uses discordant read pairs and clipped reads in combination with consensus sequences of known active mobile elements. Mobster has a low false discovery rate and high recall rate for both L1 and Alu elements. Mobster is available at http://sourceforge.net/projects/mobster.
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