4.7 Article

Detection of Infectivity in Blood of Persons with Variant and Sporadic Creutzfeldt-Jakob Disease

Journal

EMERGING INFECTIOUS DISEASES
Volume 20, Issue 1, Pages 114-117

Publisher

CENTERS DISEASE CONTROL
DOI: 10.3201/eid2001.130353

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Funding

  1. European Commission: Protecting the food chain from prions: shaping European priorities through basic and applied research (PRIORITY) [222887, FP7-KBBE-2007-2A]
  2. JPND program (DEMTEST: Biomarker based diagnosis of rapid progressive dementias-optimization of diagnostic protocols) [01ED1201A]
  3. Robert Koch-Institute through funds of the Federal Ministry of Health [1369-341]

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We report the presence of infectivity in erythrocytes, leukocytes, and plasma of 1 person with variant Creutzfeldt-Jakob disease and in the plasma of 2 in 4 persons whose tests were positive for sporadic Creutzfeldt-Jakob disease. The measured infectivity levels were comparable to those reported in various animals with transmissible spongiform encephalopathies.

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