Journal
CHEMBIOENG REVIEWS
Volume 1, Issue 1, Pages 6-13Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cben.201300006
Keywords
Biofuel; Cellulase; Cellulose degradation; Cellulosome; Consolidated bioprocessing
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Funding
- DFG
- Fonds der Chemischen Industrie
- Deutsche Forschungsgemeinschaft, DFG EXC 1003 Cells in Motion - Cluster of Excellence, Munster, Germany [RE2796/2-1]
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Degradation of cellulose represents a key step for efficient generation of biofuels such as ethanol or butanol from nonfood crops. Several strategies aim to improve the performance of cellulases in order to make the overall process more cost-efficient. In one strategy, novel arrangements of cellulases are developed. The resulting so-called designer cellulosomes might allow to equip the fermenting hosts with sufficient cellulase activity to grow on cellulose as sole carbon source and thus enable consolidated bioprocessing. Other strategies aim to engineer cellulases with higher thermostability and activity to make cellulose hydrolysis more efficient. This review summarizes current developments in the field of cellulase engineering and highlight achievements as well as limitations.
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