Journal
EMERGING INFECTIOUS DISEASES
Volume 20, Issue 2, Pages 217-224Publisher
CENTERS DISEASE CONTROL
DOI: 10.3201/eid2002.121797
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Funding
- National Natural Science Foundation of China [31229005, 31110103901, 31302078]
- State Key Laboratory of Veterinary Etiological Biology, Lanzhou, China
- Fundamental Research Funds for the Central Universities, China
- Ministry of Education, Youth and Sports of the Czech Republic [LH11061]
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Cryptosporidium ubiquitum is an emerging zoonotic pathogen. In the past, it was not possible to identify an association between cases of human and animal infection. We conducted a genomic survey of the species, developed a subtyping tool targeting the 60-kDa glycoprotein (gp60) gene, and identified 6 subtype families (XIIa-XIIf) of C. ubiquitum. Host adaptation was apparent at the gp60 locus; subtype XIIa was found in ruminants worldwide, subtype families XIIb-XIId were found in rodents in the United States, and XIIe and XIIf were found in rodents in the Slovak Republic. Humans in the United States were infected with isolates of subtypes XIIb-XIId, whereas those in other areas were infected primarily with subtype XIIa isolates. In addition, subtype families XIIb and XIId were detected in drinking source water in the United States. Contact with C. ubiquitum-infected sheep and drinking water contaminated by infected wildlife could be sources of human infections.
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