Journal
CLINICAL AND TRANSLATIONAL IMAGING
Volume 2, Issue 1, Pages 67-76Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s40336-014-0051-5
Keywords
Nanomedicine; Drug targeting; Theranostics; Image-guided drug delivery; Personalized medicine
Funding
- German Federal State of North Rhine Westphalia
- German Academic Exchange Service (DAAD) [290084/2011-3]
- DFG [LA 2937/1-2]
- European Union
- European Research Council (ERC) [309495: NeoNaNo]
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Advances in nanotechnology and chemical engineering have led to the development of many different drug delivery systems. These 1-100(0)-nm-sized carrier materials aim to increase drug concentrations at the pathological site, while avoiding their accumulation in healthy non-target tissues, thereby improving the balance between the efficacy and the toxicity of systemic (chemo-)therapeutic interventions. An important advantage of such nanocarrier materials is the ease of incorporating both diagnostic and therapeutic entities within a single formulation, enabling them to be used for theranostic purposes. We here describe the basic principles of using nanomaterials for targeting therapeutic and diagnostic agents to pathological sites, and we discuss how nanotheranostics and image-guided drug delivery can be used to personalize nanomedicine treatments.
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