Journal
NATURE REVIEWS CANCER
Volume 14, Issue 2, Pages 108-119Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3648
Keywords
-
Categories
Funding
- Cancer Prevention and Research Institute of Texas (CPRIT) [RP110202]
- USA Department of Defense CDMRP [W81XWH-12-1-0508]
- Voelcker Fund
- Greehey Children Cancer Research Institute (GCCRI)
Ask authors/readers for more resources
The neuroendocrine tumours pheochromocytomas and paragangliomas carry the highest degree of heritability in human neoplasms, enabling genetic alterations to be traced to clinical phenotypes through their transmission in families. Mutations in more than a dozen distinct susceptibility genes have implicated multiple pathways in these tumours, offering insights into kinase downstream signalling interactions and hypoxia regulation, and uncovering links between metabolism, epigenetic remodelling and cell growth. These advances extend to co-occurring tumours, including renal, thyroid and gastrointestinal malignancies. Hereditary pheochromocytomas and paragangliomas are powerful models for recognizing cancer driver events, which can be harnessed for diagnostic purposes and for guiding the future development of targeted therapies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available