Journal
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 127, Issue -, Pages 16-18Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jri.2018.04.001
Keywords
Microbial translocation; HIV; Progesterone; Pregnancy
Categories
Funding
- NIH [R01HD043921, AI091526, AI128864]
- South Carolina Clinical and Translational Research Institute Pilot Grant Program [UL1 TR000062]
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In HIV infection, increased adverse perinatal outcomes reported among HIV-associated pregnancies are not fully understood. Currently, microbial product translocation (MT) from a permeable mucosa is demonstrated as a driver of inflammation, and may contribute to preterm delivery in HIV. Here, our results showed that plasma LPS levels (a representative marker of MT) were increased in HIV-infected women in the first and second trimester. Progesterone levels were significantly decreased in HIV-infected subjects in the first trimester and second trimester. There were significant inverse correlations between plasma LPS and progesterone in the first and second trimester. These results suggested heightened systemic MT and decreased plasma progesterone levels in HIV infected pregnant women may play a role in increased incidence of preterm delivery.
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