Journal
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
Volume 38, Issue 3, Pages 256-265Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10799893.2018.1478856
Keywords
Methyl gallate; lipoxygenase inhibition; isothermal titration calorimetry; molecular dynamics
Categories
Funding
- Council for Scientific and Industrial Research (India) [09/979(0007)/216-EMR-I (SRF)]
Ask authors/readers for more resources
Methyl gallate was purified, by lipoxygenase (LOX) inhibitory activity-guided method since its alleged anti-inflammatory property, from Bergenia ligulata (Wall), a plant used in the traditional, Ayurvedic system of medicine extensively. The LOX inhibitory property of methyl gallate was studied by enzyme kinetics, isothermal titration calorimetry and molecular docking followed by molecular simulation studies. The wet-laboratory experiments and in silica studies showed complete agreement, and promise of methyl gallate as a drug-lead molecular scaffold for anti-inflammatory therapy, based on LOX inhibition. The expressed work shows the need of nonactive site binding parameters to be considered while designing of inhibitors based on the specificities toward active sites of enzymes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available