Journal
ACS NANO
Volume 8, Issue 3, Pages 2998-3005Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn5002968
Keywords
nanomedicine; contact lens; nanodiamond; drug delivery; biomaterials
Categories
Funding
- National Science Foundation CAREER Award [CMMI-0846323]
- Center for Scalable and Integrated Nano-Manufacturing [DMI-0327077, CMMI-0856492, DMR-1105060]
- V Foundation for Cancer Research Scholars Award
- Wallace H. Coulter Foundation Translational Research Award
- Society for Laboratory Automation and Screening (SLAS) Endowed Fellowship
- Beckman Coulter, and National Cancer Institute [U54CA151880]
- Agency for Science, Technology and Research (A*STAR)
- National Cancer Institute [1F30CA174156]
- Direct For Mathematical & Physical Scien [1343991] Funding Source: National Science Foundation
- Directorate For Engineering [1350197] Funding Source: National Science Foundation
- Division Of Materials Research [1343991] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn [1350197] Funding Source: National Science Foundation
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Temporarily implanted devices, such as drug-loaded contact lenses, are emerging as the preferred treatment method for ocular diseases like glaucoma. Localizing the delivery of glaucoma drugs, such as timolol maleate (TM), can minimize adverse effects caused by systemic administration. Although eye drops and drug-soaked lenses allow for local treatment, their utility is limited by burst release and a lack of sustained therapeutic delivery. Additionally, wet transportation and storage of drug-soaked lenses result in drug loss due to elution from the lenses. Here we present a nanodiamond (ND)-embedded contact lens capable of lysozyme-triggered release of TM for sustained therapy. We find that ND-embedded lenses composed of enzyme-cleavable polymers allow for controlled and sustained release of TM in the presence of lysozyme. Retention of drug activity is verified in primary human trabecular meshwork cells. These results demonstrate the translational potential of an ND-embedded lens capable of drug sequestration and enzyme activation.
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