Journal
NATURE REVIEWS IMMUNOLOGY
Volume 14, Issue 3, Pages 166-180Publisher
NATURE PORTFOLIO
DOI: 10.1038/nri3607
Keywords
-
Categories
Funding
- Australian National Health and Medical Research Council [1013584]
- Wellcome Trust, UK [WT094415]
- Medical Research Council, UK [G0601481, MR/K013386/1]
- US National Institutes of Health [GM107848, GM64709, MH096484, HD074981]
- MRC [G0601481, MR/K013386/1] Funding Source: UKRI
- Medical Research Council [G0601481, MR/K013386/1] Funding Source: researchfish
Ask authors/readers for more resources
The prompt removal of apoptotic cells by phagocytes is important for maintaining tissue homeostasis. The molecular and cellular events that underpin apoptotic cell recognition and uptake, and the subsequent biological responses, are increasingly better defined. The detection and disposal of apoptotic cells generally promote an anti-inflammatory response at the tissue level, as well as immunological tolerance. Consequently, defects in apoptotic cell clearance have been linked with various inflammatory diseases and autoimmunity. Conversely, under certain conditions, such as the killing of tumour cells by specific cell-death inducers, the recognition of apoptotic tumour cells can promote an immunogenic response and antitumour immunity. Here, we review the current understanding of the complex process of apoptotic cell clearance in physiology and pathology, and discuss how this knowledge could be harnessed for new therapeutic strategies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available