Journal
METABOLITES
Volume 4, Issue 1, Pages 71-97Publisher
MDPI
DOI: 10.3390/metabo4010071
Keywords
urine; metabolomics; microextraction by packed sorbent; solid-phase microextraction
Categories
Funding
- Portuguese Foundation for Science and Technology (FCT) through the MS Portuguese Networks [REDE/1508/RNEM/2010]
- New-INDIGO/0003/2012 project (ERA-NET, FP 7)
- [PEst-OE/QUI/UI0674/2011]
- Fundação para a Ciência e a Tecnologia [PEst-OE/QUI/UI0674/2011] Funding Source: FCT
Ask authors/readers for more resources
For a long time, sample preparation was unrecognized as a critical issue in the analytical methodology, thus limiting the performance that could be achieved. However, the improvement of microextraction techniques, particularly microextraction by packed sorbent (MEPS) and solid-phase microextraction (SPME), completely modified this scenario by introducing unprecedented control over this process. Urine is a biological fluid that is very interesting for metabolomics studies, allowing human health and disease characterization in a minimally invasive form. In this manuscript, we will critically review the most relevant and promising works in this field, highlighting how the metabolomic profiling of urine can be an extremely valuable tool for the early diagnosis of highly prevalent diseases, such as cardiovascular, oncologic and neurodegenerative ones.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available