Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 122, Issue 26, Pages 6763-6770Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcb.8b03733
Keywords
-
Categories
Funding
- Science and Engineering Research Board [YSS/2014/000098]
- German Academic Exchange Service (DAAD) [57314018]
- Council of Scientific and Industrial Research (CSIR), India [09/254(0267)/2017-EMR-I]
- University Grants Commission (UGC), India [105743]
Ask authors/readers for more resources
The interaction of amphiphilic ionic liquids containing an 1-alkyl-3-methylimidazolium cation ([C12MIM](+)), which shows acute cytotoxicity toward marine and bacterial life, with zwitterionic 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-choline (POPC) and anionic l-palmitoyl-2-oleoyl-sn-glycero-3-phosphorac-glycerol (POPG) membranes was investigated. Biophysical parameters of this interaction were quantified by fluorescence spectroscopy, isothermal titration calorimeter, and solution-state NMR measurements. [C12MIM](+) inserts into the membrane and induces vesicle leakage at relatively low concentration (< 1 mM). Zwitterionic POPC membranes are more leakage-prone, but the binding of [C12MIM](+) cations is stronger to anionic POPG membranes. A higher rate of exchange of membrane-bound [C12MIM] (+) is suspected to play a key role in membrane leakage. Furthermore, solid-state NMR spectroscopy was employed to determine the location of [C12MIM](+) in lipid membranes and its impact on the structure and dynamics of the bilayer. The study provides a molecular understanding of the membrane permeabilizing effect of the [C12MIM](+) mediated by its detergent-like structure.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available