Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 122, Issue 22, Pages 5727-5737Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcb.8b01657
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Funding
- Science and Engineering Research Board (Govt. of India) [EMR/2016/002294]
- SERB Distinguished Fellowship (Department of Science and Technology, Govt. of India)
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Gprotein-coupled receptors (GPCRs) are seven transmembrane receptors that mediate a large number of cellular responses and are important drug targets. One of the current challenges in GPCR biology is to analyze the molecular signatures of receptor-lipid interactions and their subsequent effects on GPCR structure, organization, and function. Molecular dynamics simulation studies have been successful in predicting molecular determinants of receptor-lipid interactions. In particular, predicted cholesterol interaction sites appear to correspond well with experimentally determined binding sites and estimated time scales of association. In spite of several success stories, the methodologies in molecular dynamics simulations are still emerging. In this Feature Article, we provide a comprehensive overview of coarse-grain and atomistic molecular dynamics simulations of GPCR-lipid interaction in the context of experimental observations. In addition, we discuss the effect of secondary and tertiary structural constraints in coarse-grain simulations in the context of functional dynamics and structural plasticity of GPCRs. We envision that this comprehensive overview will help resolve differences in computational studies and provide a way forward.
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