Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 122, Issue 8, Pages 2219-2226Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcb.7b11889
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Funding
- National Institute of General Medical Sciences [GM095496]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM095496] Funding Source: NIH RePORTER
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Fengycin is a cyclic lipopeptide used as an agricultural fungicide. It is synthesized by Bacillus subtilis as an immune response against fungal infection and functions by damaging the target's cell membrane. Previous molecular dynamics simulations and experiments have led to the hypothesis that the aggregation of fengycins on the membrane surface plays a key role in cell disruption. Here, we used microsecond-scale all-atom molecular dynamics simulations to understand the specificity, selectivity, and structure of fengycin oligomers. Our simulations suggest that fengycin is more likely to form stable oligomers in model fungal membranes (phosphatidylcholine) compared to the model bacterial membranes (phosphatidylethanolamine:phosphatidylglycerol). Furthermore, we characterize the differences in the structure and kinetics of the membrane-bound aggregates and discuss their functional implications.
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