Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
Volume 180, Issue -, Pages 225-234Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2018.02.012
Keywords
Artemisia herba-alba; LC-DAD-MS; H-1 NMR; Antibacterial activity; Dengue; Green synthesis; Larvicide; Malaria; Pesticide; Zika virus
Categories
Funding
- Deanship of Scientific Research (DSR), University of Tabuk, Tabuk, Kingdom of Saudi Arabia [S-0068-1437]
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The development of eco-friendly and effective insecticides is crucial for public health worldwide. Herein, we focused on the desert wormwood (Artemisia herba-alba), a plant widely used in Arabian traditional medicine, as a source of green nanoinsecticides against mosquito vectors, as well as growth inhibitors to be employed against microbial pathogens. Ag nanoparticles (AgNPs) fabricated with the A. herba-albs extract were tested on Indian and Saudi Arabian strains of Anopheles, Aedes and Culex mosquitoes. The chemical profile of the A. herba-alba extract was determined by LC-DAD-MS and H-1 NMR studies. Then, AgNPs were studied using UV-vis spectroscopy, XRD, FTIR spectroscopy, TEM, and EDX analyses. Artemisia herba-alba-synthesized AgNPs showed high larvicidal toxicity against mosquitoes from both Indian and Saudi Arabian strains. LC50 of AgNPs against Indian strains was 9.76 mu g/ml for An. stephensi, 10.70 mu g/ml for Ae. aegypti and 11.43 mu g/ml for Cx. quinquefasciatus, whereas against Saudi Arabian strains it was 33.58 mu g/ml for Ae. aegypti and 38.06 mu g/ml for Cx. pipiens. In adulticidal experiments, A. herba-alba extract showed LC50 ranging from 293.02 to 450 mu g/ml, while AgNP LC50 ranged from 8.22 to 27.39 mu g/ml. Further, low doses of the AgNPs inhibited the growth of selected microbial pathogens. Overall, A. herba-alba can be further considered as a source of phytochemicals, with special reference to saponins, for effective and prompt fabrication of AgNPs with relevant insecticidal and bactericidal activity against species of high public health importance.
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