Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Volume 364, Issue -, Pages 635-644Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotochem.2018.07.004
Keywords
Pyrrolocoumarin; Cu2+; Fluorescence; Turn-off; Cell imaging
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Funding
- University Grants Commission (UGC), New Delhi, India
- UGC, India [F.4-2/2006(BSR)/CH/15-16/0226]
- UGC
- UGC, New Delhi, India [F.42/2006 (BSR)/CH/1415/ 0215]
- Centre of Advanced Study (CAS-V, UGC, New Delhi) at Department of Chemistry, University of Calcutta
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A novel pyrrole fused coumarin based simple and practicable molecular probe has been synthesized under metal free green conditions which can recognize copper (II) in acetonitrile solvent. The synthesized probe displayed fluorescence quenching through selective binding with Cu2+ over other competitive metal ions. Job's plot, H-1 NMR titration and Mass spectral study revealed that the most abundant species formed when metal to ligand ratio was 1:1. The limit of detection (LOD) for Cu2+ was found to be 11.3 nM or 2 ppb which is significantly lower than the maximum contaminant level (1.3 ppm of Cu), according to United State Environmental Protection Agency (USEPA). The fluorescent sensor was highly cell permeable and illustrated fluorescence 'Turn-Off in presence of Cu2+ ions in fluorescent imaging of human cervical cancer (HeLa) cell.
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