4.6 Article

A sensitive BODIPY-based fluorescent probe suitable for hypochlorite detection in living cells

Journal

Publisher

ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotochem.2017.10.037

Keywords

Fluorescent probe; Hypochlorite; BODIPY; Bioimaging

Funding

  1. National Natural Science Foundation of China [31470434, 21576124, 21507047, 21676124]
  2. China Postdoctoral Science Foundation [2017M610308]
  3. Zhenjiang Social development project [SH2016019]
  4. Science Foundation of Jiangsu Entry-exit Inspection Quarantine Bureau [2016KJ51, 2017KJ47]

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A fluorescent probe composed of BODIPY and 2,4-dinitrophenylhydrazine was designed for the detection of CIO-. The oxidizing reaction between probe and CIO- resulted in a distinct fluorescence enhancement together with a color variation from pink to orange. This probe showed excellent selectivity to CIO- among various ions including common reactive oxygen species and high sensitivity with a detection limit of 228 nM. A fast response (7 min) was observed, which made the probe a promising method in real-time detection. Furthermore, this probe was successfully applied to monitor CIO- in real-life water and living cells. (C) 2017 Elsevier B.V. All rights reserved.

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