Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 159, Issue -, Pages 296-304Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2018.07.006
Keywords
Traditional Chinese medicines; Quality control markers; Fingerprint-efficacy modeling; Chemometric methods
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Funding
- National Natural Science Foundation of China [81322051]
- Twelfth-Five Years National Key Subject of Drug Innovation [2015ZX09101043-010]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
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Quality control (QC) is crucial for ensuring the safety and effectiveness of traditional Chinese medicines (TCMs). Due to extremely complicated phytochemical matrices and characteristic mode of multi-component, multi-target, integrated adjustment, discovering of QC markers from TCMs is a big challenge. Fingerprint-efficacy (FE) modeling method is currently proposed as an effective and reasonable attempt. This review summarizes the methodologies of FE modeling and applications in screening QC markers, meanwhile the future perspectives are also briefly discussed so as to provide inspiration and reference for follow-up study of FE relationship for TCMs. (C) 2018 Elsevier B.V. All rights reserved.
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