Journal
JOURNAL OF PESTICIDE SCIENCE
Volume 43, Issue 1-2, Pages 1-9Publisher
PESTICIDE SCI SOC JAPAN
DOI: 10.1584/jpestics.D17-078
Keywords
enzyme transformation; enzymatic detoxification; pesticide detoxification; organophosphorus
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Funding
- National Council of Science and Technology of Mexico [IFC 2015-1, CB-251241]
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Millions of cases of pesticide intoxication occur yearly and represent a public health problem. In addition, pesticide poisoning is the preferred suicidal method in rural areas. The use of enzymes for the treatment of intoxication due to organophosphorus pesticides was proposed decades ago. Several enzymes are able to transform organophosphorus compounds such as pesticides and nerve agents. Some specific enzymatic treatments have been proposed, including direct enzyme injection, liposome and erythrocytes carriers, PEGylated preparations and extracorporeal enzymatic treatments. Nevertheless, no enzymatic treatments are currently available. In this work, the use of enzymes for treating of organophosphorus pesticide intoxication is critically reviewed and the remaining challenges are discussed. (C) Pesticide Science Society of Japan
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