Journal
NATURE REVIEWS CANCER
Volume 14, Issue 4, Pages 233-247Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3700
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Funding
- National Natural Science Foundation of China (NSFC) [81172087]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- US National Institutes of Health (NIH) [GM089763, GM094777, CA177910]
- American Cancer Society (ACS) research scholar
- Leukemia & Lymphoma Society (LLS) research scholar
- [5T32HL007893]
- [AG041218]
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F-box proteins, which are the substrate-recognition subunits of SKP1-cullin 1-F-box protein (SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through ubiquitylation and subsequent degradation of target proteins. Dysregulation of F-box protein-mediated proteolysis leads to human malignancies. Notably, inhibitors that target F-box proteins have shown promising therapeutic potential, urging us to review the current understanding of how F-box proteins contribute to tumorigenesis. As the physiological functions for many of the 69 putative F-box proteins remain elusive, additional genetic and mechanistic studies will help to define the role of each F-box protein in tumorigenesis, thereby paving the road for the rational design of F-box protein-targeted anticancer therapies.
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