4.7 Article

Redox-Neutral Cyanoalkylation/Cyclization of Olefinic 1,3-Dicarbonyls with Cycloketone Oxime Esters: Access to Cyanoalkylated Dihydrofurans

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 83, Issue 7, Pages 4239-4249

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b00271

Keywords

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Funding

  1. Natural Science Basic Research Plan in Shaanxi Province of China [2016JZ002]
  2. Fundamental Research Funds of the Central Universities [zrzd2017001, xjj2016056, 2015qngz17]

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Metal-catalyzed cyanoalkylation/cyclization of olefinic 1,3-dicarbonyls with cydoketone oxime esters has been developed under redox-neutral conditions. This protocol provided a straightforward approach to diverse cyanoalkylated 2,3-dihydrofurans via a tandem ring-opening/addition/cyclization process.

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