Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 83, Issue 13, Pages 7033-7041Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b03202
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Funding
- International Max-Planck-Research School in Chemical and Molecular Biology
- European Research Council under the Seventh Framework Programme of the European Union (FP7
- ERC Grant) [268309]
- Max Planck Society
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A novel enantioselective approach to the synthesis of a compound collection inspired by natural pyrrolizidine alkaloids was developed, employing an enantioselectively catalyzed 1,3-dipolar cycloaddition as the key step. The cycloadducts were obtained with excellent enantio- and diastereoselectivity. Biological evaluation of the resulting compound collection revealed that the compound class has multiple bioactivities, including activity against Plasmodium falciparum 3D7 and inhibition of Hedgehog signaling.
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