Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 83, Issue 5, Pages 2582-2591Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b02863
Keywords
-
Categories
Funding
- Tsinghua University Initiative Scientific Research. Program
- National Natural Science Foundation of China [81773567, 81622042, 81573277]
- National Major Scientific and Technological Special Project for Significant New Drugs Development [SQ2017ZX095003]
Ask authors/readers for more resources
A strategy combining O- and N-containing directing groups has been developed for the synthesis of 2,2'-biaryl via Pd-mediated C-H bond activation and oxidative coupling. This new transformation may proceed through a mechanism involving Pd(II) and Pd(IV) intermediates. We found the use of PTSA and HFIP to be critical for the reaction and suggest that these reagents could serve as efficient ligands for this C-C bond formation. This methodology provides broad functional group tolerance, excellent reactivity, and high yields.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available