Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 83, Issue 8, Pages 4851-4858Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b00430
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Funding
- Fonds der Chemischen Industrie
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4-Pyrazolyl-1,2,3-triazoles can be readily synthesized in a one-pot fashion and moderate yield by employing a consecutive four-component process consisting of a sequentially Pd-Cu-catalyzed alkynylation-cyclocondensation-desilylation-CuAAC process. Most distinctly, (triisopropylsilyl)butadiyne is employed as a four-carbon building block in this one-pot de novo formation of both heterocyclic moieties.
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