Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 83, Issue 7, Pages 4034-4043Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b00422
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Funding
- National Natural Science Foundation of China [21572200]
- Fundamental Research Funds for the Central Universities [2017QNA3013]
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With the vastly increasing applications of chiral phosphine-oxazoline (PHOX) hybrid ligands in various transition metal-catalyzed reactions, novel PHOX ligands bearing innovative backbones are highly valuable and in great demand. This study describes the development of a new type of chiral PHOX ligands based on a hexamethyl-1,1'-spirobiindane scaffold and incorporating both a phosphine and an oxazoline moiety. The optimal ligand provided high yields and excellent enantioselectivities for the Ni-catalyzed asymmetric arylation of cyclic N-sulfonyl imines with arylboronic acids leading to chiral amines.
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