Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 83, Issue 7, Pages 4119-4130Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b00020
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- [21572027]
- [81741169]
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A convenient synthesis of 3,4-dihydro-2H-naphtho[2,3-b] [1,4]oxazine-5,10-diones and 2,3,4,5-tetrahydro-1H-naphtho[2,3-b]azepine-6,11-diones via the copper-catalyzed intramolecular C-O/C-C coupling reaction is described. This method showed a good tolerance for functional groups and was applied to the synthesis of natural product core structures. Some coupling products exhibited moderate activities against lung cancer A549 cells.
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