Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 83, Issue 2, Pages 765-782Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b02783
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Funding
- Office of the Higher Education Commission
- Mahidol University under the National Research Universities Initiative
- Center of Excellence for Innovation in Chemistry (PERCH-CIC)
- Thailand Research Found [IRN58W0005]
- Franco-Thai Cooperation Program in Higher Education and Research (PHC-Siam)
- Royal Golden Jubilee Ph.D. Program [PHD/0121/2554]
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[GRAPHICS] An efficient C1-difluoromethylation of tetrahydroisoquinolenes was achieved using TMSCF2SPh as a difluoromethylating agent and 2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate (TEMPO+BF4-) as an oxidant. The process provides an access to a variety of C1-difluoro(phenylsulfanyl)methylated tetrahydroisoquinoline adducts in good yields. These adducts' were employed as key precursors for preparing fluorinated pyrrolo[2,1-a]isoquinoline and benzo [a] quinolizidines.
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