4.7 Article

Copper-Catalyzed Synthesis of Multisubstituted Indoles through Tandem Ullmann-Type C-N Formation and Cross-dehydrogenative Coupling Reactions

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 83, Issue 9, Pages 5288-5294

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b00353

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Funding

  1. Fundamental Research Funds for the Central Universities [2572015EB02]
  2. Natural Science Foundation of Heilongjiang Province [B2017002]

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Multisubstituted indoles were synthesized via a one-pot tandem copper-catalyzed Ullmann-type C-N bond formation/intramolecular cross-dehydrogenative coupling process at 130 degrees C in DMSO. The methodology allows practical and modular assembly of indoles in good to excellent yields from readily available aryl iodides and enamines.

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