Journal
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume 54, Issue -, Pages 1-10Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2017.10.004
Keywords
Epigenetic marker; DNA methylation; Reprogramming; Metabolic disorders; Intervention
Funding
- USDA National Institute of Food and Agriculture Hatch Project [1007334]
- NIH [5R18DK091811-02]
- NIFA [912398, 1007334] Funding Source: Federal RePORTER
Ask authors/readers for more resources
Environmental factors (e.g., malnutrition and physical inactivity) contribute largely to metabolic disorders including obesity, type 2 diabetes, cardiometabolic disease and nonalcoholic fatty liver diseases. The abnormalities in metabolic activity and pathways have been increasingly associated with altered DNA methylation, histone modification and noncoding RNA5, whereas lifestyle interventions targeting diet and physical activity can reverse the epigenetic and metabolic changes. Here we review recent evidence primarily from human studies that links DNA methylation reprogramming to metabolic derangements or improvements, with a focus on cross-tissue (e.g., the liver, skeletal muscle, pancreas, adipose tissue and blood samples) epigenetic markers, mechanistic mediators of the epigenetic reprogramming, and the potential of using epigenetic traits to predict disease risk and intervention response. The challenges in epigenetic studies addressing the mechanisms of metabolic diseases and future directions are also discussed and prospected. (C) 2017 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available