Journal
JOURNAL OF NUCLEAR MEDICINE
Volume 59, Issue 7, Pages 1007-1013Publisher
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.117.203877
Keywords
prostate cancer; angiogenesis; tumor neovasculature; endoradiotherapy; inflammatory bowel disease; folate
Funding
- NIH [R01 CA138444]
Ask authors/readers for more resources
In this review, we cover the evolution of knowledge on the biology of prostate-specific membrane antigen (PSMA) and its translation to therapy. The usual key to discovery is a realistic model for experimentation and for testing a hypothesis. A realistic model is especially needed in the case of the human prostate, which differs significantly from the prostate of species often used as research models. We will emphasize the genetic characterization of PSMA, the nature of the PSMA protein, and its role as a carboxypeptidase, with differing important substrates and products in different tissues. We give special prominence to the importance of PSMA as a target for imaging and therapy in prostate cancer and its underdeveloped role for imaging and targeting the neovasculature of tumors other than prostate cancer. Lastly, we bring attention to its importance in other nonprostatic tissues.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available