Journal
JOURNAL OF NUCLEAR CARDIOLOGY
Volume 26, Issue 4, Pages 1269-1279Publisher
SPRINGER
DOI: 10.1007/s12350-018-1189-8
Keywords
Coronary artery disease; fractional flow reserve; SPECT; new camera CZT; dual isotope
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Background The aim of this study was to determine the diagnostic accuracy of stress thallium-201/rest technetium-99m-sestamibi sequential dual-isotope high-speed myocardial perfusion imaging (DI-HS-MPI) against invasively determined fractional flow reserve (FFR). MethodsFifty-four consecutive patients prospectively underwent DI-HS-MPI before invasive coronary angiography. Perfusion was scored visually by summed stress score on a patient and coronary territory basis. Significant coronary artery disease (CAD) was defined by the presence of >= 90% stenosis/occlusion or fractional flow reserve <= 0.80 for coronary stenosis >= 50%. ResultsFFR was measured in 69 of 162 coronary vessels, with 1.280.56 vessels assessed/patient. Sensitivity, specificity, and diagnostic accuracy of MPI for the detection of significant CAD were 92.8%, 69.2%, and 81.4%, on a patient basis, and 83.7%, 90.4%, and 88.8% by coronary territory. Conclusions DI-HS-MPI accurately detects functionally significant CAD as defined by using FFR.
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