Journal
REUMATOLOGIA CLINICA
Volume 10, Issue 3, Pages 174-179Publisher
ELSEVIER DOYMA SL
DOI: 10.1016/j.reuma.2014.01.009
Keywords
Rheumatoid artritis; Animal models; Collagen-induced arthritis; Transforming growth factor-beta; T cells
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Transforming growth factor-beta (TGF-beta) is a cytokine with pleiotropic functions in hematopoiesis, angiogenesis, cell proliferation, differentiation, migration and apoptosis. Although its role in rheumatoid arthritis is not well defined, TGF-beta activation leads to functional immunomodulatory effects according to environmental conditions. The function of TGF-beta in the development of arthritis in murine models has been extensively studied with controversial results. Recent findings point to a non-relevant role for TGF-beta in a mice model of collagen-induced arthritis. The study of TGF-beta on T-cell responses has shown controversial results as an inhibitor or promoter of the inflammatory response. This paper presents a review of the role of TGF-beta in animal models of arthritis. (C) 2013 Elsevier Espafia, S.L. All rights reserved.
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