Journal
GREEN CHEMISTRY
Volume 17, Issue 2, Pages 945-949Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4gc01481b
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Further to the introduction of solvent and reagent guides at GSK, the reagent guide methodology has been adapted to score common acids and bases for use in situations where the chemistry is tolerant of a number of options. The pK(a) of each acid and base, and information as to whether they are generally recognised as safe are included to enhance the utility of such guides.
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