Journal
INTELLIGENCE
Volume 44, Issue -, Pages 26-32Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.intell.2014.02.006
Keywords
Generation Scotland; Intelligence; Education; Socioeconomic status; Genetics
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Funding
- MRC [G0700704, G0100266, MC_PC_U127561128] Funding Source: UKRI
- Alzheimers Research UK [ART-RF2010-2] Funding Source: researchfish
- Chief Scientist Office [CZD/16/6/4] Funding Source: researchfish
- Medical Research Council [G0100266, MR/K026992/1, G0700704, MC_PC_U127561128] Funding Source: researchfish
- Medical Research Council [MR/K026992/1, G0100266, G0700704, MC_PC_U127561128] Funding Source: Medline
- Chief Scientist Office [CZD/16/6/4] Funding Source: Medline
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Education, socioeconomic status, and intelligence are commonly used as predictors of health outcomes, social environment, and mortality. Education and socioeconomic status are typically viewed as environmental variables although both correlate with intelligence, which has a substantial genetic basis. Using data from 6815 unrelated subjects from the Generation Scotland study, we examined the genetic contributions to these variables and their genetic correlations. Subjects underwent genome-wide testing for common single nucleotide polymorphisms (SNPs). DNA-derived heritability estimates and genetic correlations were calculated using the 'Genome-wide Complex Trait Analyses' (GCTA) procedures. 21% of the variation in education, 18% of the variation in socioeconomic status, and 29% of the variation in general cognitive ability was explained by variation in common SNPs (SEs similar to 5%). The SNP-based genetic correlations of education and socioeconomic status with general intelligence were 0.95 (SE 0.13) and 0.26 (0.16), respectively. There are genetic contributions to intelligence and education with near-complete overlap between common additive SNP effects on these traits (genetic correlation 1). Genetic influences on Socioeconomic status are also associated with the genetic foundations of intelligence. The results are also compatible with substantial environmental contributions to socioeconomic status. (C) 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
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